منابع مشابه
Noncoding RNA and Cardiomyocyte Proliferation
It is acknowledged that postnatal mammalian cardiomyocytes (CMs) turn over with a very limited efficacy in both physiological and pathological conditions. Recent studies showed that those newly formed CMs are derived from preexisting CMs. Thus, stimulating CM proliferation becomes a promising strategy for inducing cardiac regeneration. Noncoding RNAs were found differently expressed in CMs with...
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CIRCULATION RESEARCH (ISSN 0009-7330 print / 1524-4571 online) is published semimonthly for 24 total issues a year by Lippincott Williams & Wilkins at 16522 Hunters Green Parkway, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. In the US, ind...
متن کاملRevisiting Preadolescent Cardiomyocyte Proliferation in Mice.
Understanding cardiomyocyte cell cycle regulation after birth is key to optimizing regenerative strategies for the heart post injury, yet poses multiple technical challenges, as evidenced by recent studies that have arrived at divergent conclusions. In a recent publication in Cell, Alkass et al undertook multiple approaches to examine cardiomyocyte cell cycle regulation in the first 3 weeks aft...
متن کاملFGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry.
AIMS Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart. Understanding the developmental processes controlling cardiomyocyte proliferation may thus identify new therapeutic targets to modulate the cell-cycle activity of cardiomyocytes in the adult heart. This study aims to determine the mechanism by which ...
متن کاملExtra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life.
One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounting evidence collected over the last several years indicates that cardiomyocyte...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.310058